Put people at your wedding together in tables of people who have similar interests, hobbies, or careers. That will give them something to talk about while they enjoy their meal at the reception, and reduces any awkward feelings for your guests. You want the day to be perfect and special for everyone in attendance!
A wedding should be a magical and memorable moment so be sure to pick out who will be a part of it wisely. If you've got that obnoxious cousin that you aren't the closest with this might be a good event to let them sit out. You don't want someone to ruin it for you.